{"id":95351,"date":"2019-10-01T23:28:15","date_gmt":"2019-10-01T23:28:15","guid":{"rendered":"https:\/\/yakujihou.com\/kinousei\/mailmagazine-backnumber\/%e6%9c%aa%e5%88%86%e9%a1%9e\/4597\/"},"modified":"2026-09-16T22:33:13","modified_gmt":"2026-09-16T13:33:13","slug":"95351","status":"publish","type":"merumaga","link":"https:\/\/www.yakujihou.com\/mailmagazines\/archive\/95351\/","title":{"rendered":"\u6a5f\u80fd\u6027\u8868\u793a\u6c34\u9762\u4e0b\u60c5\u5831 20 \u53f7\uff0f\u30d6\u30e9\u30c3\u30af\u30b8\u30f3\u30b8\u30e3\u30fc\u306e\u95a2\u4e0e\u6210\u5206"},"content":{"rendered":"
\u7279\u96c6\u3000\u30d6\u30e9\u30c3\u30af\u30b8\u30f3\u30b8\u30e3\u30fc\u306e\u95a2\u4e0e\u6210\u5206<\/div>\n
\uff11.\u30d6\u30e9\u30c3\u30af\u30b8\u30f3\u30b8\u30e3\u30fc\uff08\u307e\u305f\u306f\u9ed2\u30b7\u30e7\u30a6\u30ac\uff09<\/div>\n
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<\/p>\n

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   \u8a00\u3048\u308b\u3002<\/div>\n
\uff12.\u6700\u521d\u306e\u5c4a\u51fa\u306fB62\uff08\u5c4a\u51fa\u65e5\uff1b2016\u5e746\u67082\u65e5\u3001<\/div>\n
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   \u63a1\u7528\u6587\u732e\u306f1\u5831\uff08J Wattanathorn 2012\uff09<\/div>\n
   \u3060\u3063\u305f\u3002<\/div>\n

<\/p>\n

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   \u306a\u304b\u3063\u305f\u3002<\/div>\n

<\/p>\n

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   1\u670831\u65e5\uff09\u304c\u5c4a\u3051\u51fa\u3055\u308c\u305f\u3002<\/div>\n
\uff13.B496\u4ee5\u964d\u3001\u6d88\u8cbb\u8005\u5e81\u3068\u539f\u6599\u30e1\u30fc\u30ab\u30fc\u3068\u306e\u9593\u3067<\/div>\n
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<\/p>\n

   1\u5e748\u304b\u6708\u5f8c\u306bD187\uff08\u5c4a\u51fa\u65e5\uff1b2018\u5e749\u670812\u65e5\uff09<\/div>\n
   \u304c\u5c4a\u3051\u51fa\u3055\u308c\u308b\u3002<\/div>\n

<\/p>\n

   \u63a1\u7528\u6587\u732e\u306f\u305d\u308c\u307e\u3067\u306eSR\u3068\u540c\u3058\u304f<\/div>\n
   J Wattanathorn 2012\u306e1\u5831\u306e\u307f\u3067\u3042\u308b\u304c\u3001<\/div>\n
   \u95a2\u4e0e\u6210\u5206\u304c\u30d6\u30e9\u30c3\u30af\u30b8\u30f3\u30b8\u30e3\u30fc\u7531\u6765<\/div>\n
   \u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u306b\u66f4\u65b0\u3055\u308c\u305f\u3002<\/div>\n

<\/p>\n

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   5,7-\u30b8\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u4ee5\u5916\u306e\u6210\u5206\u3082<\/div>\n
   \u6a5f\u80fd\u6027\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u8aac\u660e\u304c<\/div>\n
   \u52a0\u308f\u3063\u305f\u3002<\/div>\n

<\/p>\n

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   \u30d6\u30e9\u30c3\u30af\u30b8\u30f3\u30b8\u30e3\u30fc\u7531\u6765\u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3<\/div>\n
   \uff083,5,7-\u30c8\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u3001<\/div>\n
   3,5,7,4-\u30c6\u30c8\u30e9\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u3001<\/div>\n
   3,5,7,3,4-\u30da\u30f3\u30bf\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u3001<\/div>\n
   5,7-\u30b8\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u3001<\/div>\n
   5,7,4-\u30c8\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u3001<\/div>\n
   5,7,3,4-\u30c6\u30c8\u30e9\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\uff09\u304c<\/div>\n
   \u542b\u6709\u300d\u3055\u308c\u3066\u304a\u308a\u3001\u300c\u30d6\u30e9\u30c3\u30af\u30b8\u30f3\u30b8\u30e3\u30fc<\/div>\n
   \u62bd\u51fa\u7269\u53ca\u3073\u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u306b\u306f<\/div>\n
   \u3044\u305a\u308c\u3082\u6709\u610f\u306a\u8102\u80aa\u5206\u89e3\u4fc3\u9032\u4f5c\u7528\u304c\u8a8d\u3081\u3089\u308c\u3001<\/div>\n
   \u30d6\u30e9\u30c3\u30af\u30b8\u30f3\u30b8\u30e3\u30fc\u62bd\u51fa\u7269\u304a\u3088\u3073<\/div>\n
   \u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u306f\u540c\u7b49\u306e\u4f5c\u7528\u3092<\/div>\n
   \u6709\u3057\u3066\u304a\u308a\u3001\u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u4ee5\u5916\u306e<\/div>\n
   \u6210\u5206\u306f\u6a5f\u80fd\u6027\u306b\u95a2\u4e0e\u3057\u306a\u304b\u3063\u305f\u3053\u3068\u304b\u3089<\/div>\n
   \u30d6\u30e9\u30c3\u30af\u30b8\u30f3\u30b8\u30e3\u30fc\u62bd\u51fa\u7269\u306e\u8102\u80aa\u5206\u89e3\u4fc3\u9032<\/div>\n
   \u4f5c\u7528\u306b\u5bfe\u3059\u308b\u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u306e<\/div>\n
   \u5bc4\u4e0e\u7387\u306f\u307b\u307c100%\u3067\u3042\u308b\u300d\u3068\u3057\u3066\u3044\u308b\u3002<\/div>\n

<\/p>\n

   \u4ee5\u964d\u3001\u540c\u69d8\u306eSR\u3067\u591a\u6570\u306e\u5546\u54c1\u304c\u5c4a\u51fa\u3055\u308c\u3066<\/div>\n
   \u3044\u308b\u3002<\/div>\n
\uff14.\u4ed6\u65b9\u3001\u3053\u308c\u307e\u3067\u3068\u306f\u9055\u3046\u539f\u6599\u30e1\u30fc\u30ab\u30fc\u304c\u3001<\/div>\n
   D352\uff08\u5c4a\u51fa\u65e5\uff1b2018\u5e7411\u670830\u65e5\uff09\u3092<\/div>\n
   \u5c4a\u3051\u51fa\u305f\u3002<\/div>\n

<\/p>\n

   \u6a5f\u80fd\u6027\u306e\u8868\u793a\u306f\u3001\u300c\u63e1\u308b\u529b\u30fb\u7acb\u3061\u4e0a\u304c\u308b\u529b<\/div>\n
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<\/p>\n

   \u63a1\u7528\u6587\u732e\u306f2\u5831\u3067\u3001J Wattanathorn 2012\u306e<\/div>\n
   \u4ed6\u306bToda 2016\u304c\u52a0\u308f\u3063\u305f\u3002<\/div>\n

<\/p>\n

   \u95a2\u4e0e\u6210\u5206\u306f\u30015,7-\u30b8\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u3068<\/div>\n
   5-\u30d2\u30c9\u30ed\u30ad\u30b7-7-\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u3067\u3042\u308b\u3002<\/div>\n

<\/p>\n

   \u4f5c\u7528\u6a5f\u5e8f\u3067\u306f\u3001\u300c\u9ed2\u30b7\u30e7\u30a6\u30ac\u62bd\u51fa\u7269\u306b<\/div>\n
   \u542b\u307e\u308c\u308b\u30dd\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u985e\u306e<\/div>\n
   \u6d3b\u6027\u5bc4\u4e0e\u7387\u3092\u7b97\u51fa\u3057\u305f\u7d50\u679c\u3001\u542b\u6709\u91cf\u3068<\/div>\n
   10 uM\u3067\u306eGlut4\u907a\u4f1d\u5b50\u304a\u3088\u3073PGC1alpha<\/div>\n
   \u907a\u4f1d\u5b50\u306e\u767a\u73fe\u5ea6\u5408\u3044\u304b\u3089\u3001<\/div>\n
   5,7-\u30b8\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u304c92%\u4ee5\u4e0a\u6d3b\u6027\u306b<\/div>\n
   \u5bc4\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5224\u660e\u3057\u305f\u3002<\/div>\n

<\/p>\n

   5-\u30d2\u30c9\u30ed\u30ad\u30b7-7-\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u306e<\/div>\n
   \u5bc4\u4e0e\u7387\u306f8%\u4ee5\u4e0b\u3067\u3042\u3063\u305f\u3002<\/div>\n

<\/p>\n

   \u306a\u304a\u30015-\u30d2\u30c9\u30ed\u30ad\u30b7-3,7-\u30b8\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u3001<\/div>\n
   5-\u30d2\u30c9\u30ed\u30ad\u30b7-3,7,4-\u30c8\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u3001<\/div>\n
   5-\u30d2\u30c9\u30ed\u30ad\u30b7-3,7,4,5-\u30c6\u30c8\u30e9\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u3001<\/div>\n
   3,5,7,4,5-\u30da\u30f3\u30bf\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u3001<\/div>\n
   5,7-4-\u30c8\u30ea\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u3001<\/div>\n
   3,5,7,4-\u30c6\u30c8\u30e9\u30e1\u30c8\u30ad\u30b7\u30d5\u30e9\u30dc\u30f3\u306b\u306f<\/div>\n
   Glut4\u907a\u4f1d\u5b50\u304a\u3088\u3073PGC1alpha\u907a\u4f1d\u5b50\u3068\u3082\u306b<\/div>\n
   10 uM\u3067\u6709\u610f\u306a\u767a\u73fe\u5897\u5f37\u304c\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f<\/div>\n
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   \u3068\u3057\u305f\u3002<\/div>\n
\uff15.D187\u3068D352\u306f\u5b9f\u8cea\u7684\u306b\u76f8\u5bb9\u308c\u306a\u3044\u5185\u5bb9\u3068<\/div>\n
   \u306a\u3063\u3066\u304a\u308a\u3001\u4eca\u5f8c\u306e\u6d88\u8cbb\u8005\u5e81\u306e\u5bfe\u5fdc\u304c<\/div>\n
   \u6ce8\u76ee\u3055\u308c\u308b\u3002<\/div>\n

<\/p>\n

\u304a\u60a9\u307f\u306e\u65b9\u306f\u79c1\u3069\u3082\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002<\/div>\n
info@yakujihou.com \uff08\u5c71\u5d0e\uff09\u307e\u3067<\/div>\n
\u304a\u6c17\u8efd\u306b\u304a\u554f\u3044\u5408\u308f\u305b\u304f\u3060\u3055\u3044\u3002<\/p>\n
\u3044\u304b\u304c\u3067\u3057\u305f\u304b\uff1f<\/div>\n
\u307e\u305f\u3001\u30e1\u30fc\u30eb\u3057\u307e\u3059\u306d\u3002<\/div>\n

<\/div>\n

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\u7279\u96c6\u3000\u30d6\u30e9\u30c3\u30af\u30b8\u30f3\u30b8\u30e3\u30fc\u306e\u95a2\u4e0e\u6210\u5206 \uff11.\u30d6\u30e9\u30c3\u30af\u30b8\u30f3\u30b8\u30e3\u30fc\uff08\u307e\u305f\u306f\u9ed2\u30b7\u30e7\u30a6\u30ac\uff09    \u30a8\u30ad\u30b9\u3092\u539f\u6599\u3068\u3057\u305f\u5546\u54c1\u304c\u591a\u304f\u3042\u308b\u3002    \u6a5f\u80fd\u6027\u306e\u8868\u793a\u306f\u3001\u6b69\u884c\u80fd\u529b\u306e\u7dad\u6301\u3001\u63e1\u529b\u30fb   […]<\/p>\n","protected":false},"author":6,"featured_media":0,"template":"","merumaga_category":[4],"class_list":["post-95351","merumaga","type-merumaga","status-publish","hentry","merumaga_category-kinousei-suimenka"],"_links":{"self":[{"href":"https:\/\/www.yakujihou.com\/mailmagazines\/wp-json\/wp\/v2\/merumaga\/95351","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.yakujihou.com\/mailmagazines\/wp-json\/wp\/v2\/merumaga"}],"about":[{"href":"https:\/\/www.yakujihou.com\/mailmagazines\/wp-json\/wp\/v2\/types\/merumaga"}],"author":[{"embeddable":true,"href":"https:\/\/www.yakujihou.com\/mailmagazines\/wp-json\/wp\/v2\/users\/6"}],"version-history":[{"count":1,"href":"https:\/\/www.yakujihou.com\/mailmagazines\/wp-json\/wp\/v2\/merumaga\/95351\/revisions"}],"predecessor-version":[{"id":95352,"href":"https:\/\/www.yakujihou.com\/mailmagazines\/wp-json\/wp\/v2\/merumaga\/95351\/revisions\/95352"}],"wp:attachment":[{"href":"https:\/\/www.yakujihou.com\/mailmagazines\/wp-json\/wp\/v2\/media?parent=95351"}],"wp:term":[{"taxonomy":"merumaga_category","embeddable":true,"href":"https:\/\/www.yakujihou.com\/mailmagazines\/wp-json\/wp\/v2\/merumaga_category?post=95351"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}