\u3053\u3093\u306b\u3061\u306f\u3002YDC\u306e\u30df\u30c3\u30b7\u30fc\u3067\u3059\u3002<\/p>\n\n\n\n
\u5148\u9031\u306e\u30e1\u30eb\u30de\u30ac\u3067\u3001\u6297\u9178\u5316\u4f5c\u7528\u3068\u3044\u3046\u4f5c\u7528\u6a5f\u5e8f
\u3092\u5c4a\u51fa\u8868\u793a\u306b\u7d44\u307f\u8fbc\u3080\u3053\u3068\u306e\u4e0d\u601d\u8b70\u306a\u70b9\u306b\u3064\u3044
\u3066\u7d39\u4ecb\u3057\u307e\u3057\u305f\u3002\u4eca\u56de\u306f\u3082\u3046\u5c11\u3057\u3053\u306e\u4f5c\u7528\u6a5f\u5e8f
\u306b\u3064\u3044\u3066\u6df1\u5800\u308a\u3057\u3066\u3044\u304d\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n
\u524d\u56de\u3082\u7d39\u4ecb\u3057\u307e\u3057\u305f\u304c\u3001\u73fe\u5728\u306e\u6a5f\u80fd\u6027\u8868\u793a\u98df\u54c1
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\u308a\u307e\u3059\u3002<\/p>\n\n\n\n
\u300c\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u304f\u6a5f\u80fd\u6027\u3092\u6d88\u8cbb\u8005\u306b\u6b63\u3057\u304f
\u4f1d\u3048\u308b\u305f\u3081\u306b\u4f5c\u7528\u6a5f\u5e8f\u3092\u8868\u793a\u3059\u308b\u3053\u3068\u304c\u5fc5\u8981\u306a
\u5834\u5408\u306f\u3001\u3053\u306e\u6b04\u306b\u4f5c\u7528\u6a5f\u5e8f\u3092\u542b\u3081\u3066\u8a18\u8f09\u3057\u305f\u3082
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\u3068\u3059\u308b\u6a5f\u80fd\u6027\u306b\u4f5c\u7528\u6a5f\u5e8f\u3092\u542b\u3081\u308b\u5834\u5408\u3001\u30d2\u30c8\u306b
\u304a\u3051\u308b\u4f5c\u7528\u6a5f\u5e8f\u306b\u3064\u3044\u3066\u51fa\u5178\u3092\u660e\u8a18\u306e\u4e0a\u3001in
vitro \u8a66\u9a13\u53c8\u306fin vivo \u8a66\u9a13\u306b\u3088\u308a\u4f5c\u7528\u6a5f\u5e8f\u3092
\u8a55\u4fa1\u3057\u305f\u5834\u5408\u306e\u30d2\u30c8\u3078\u306e\u5916\u633f\u6027\u306b\u3064\u3044\u3066\u8aac\u660e\u3059
\u308b\u3053\u3068\u3082\u542b\u3081\u5225\u7d19\u69d8\u5f0f\uff08V\uff09\uff0d18 \u3067\u79d1\u5b66\u7684\u306b\u8aac
\u660e\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3002\u307e\u305f\u3001\u8868\u793a\u3057\u3088\u3046\u3068\u3059\u308b\u6a5f
\u80fd\u6027\u306b\u4f5c\u7528\u6a5f\u5e8f\u3092\u542b\u3081\u308b\u5834\u5408\u3001\u305d\u306e\u4f5c\u7528\u6a5f\u5e8f\u304c
\u3042\u305f\u304b\u3082\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u304f\u6a5f\u80fd\u6027\u306e\u8868\u793a\u3067\u3042
\u308b\u3068\u6d88\u8cbb\u8005\u306b\u8aa4\u8a8d\u3092\u4e0e\u3048\u308b\u3088\u3046\u306a\u8868\u793a\u3092\u3057\u3066\u306f
\u306a\u3089\u306a\u3044\u3002\u300d<\/p>\n\n\n\n
\u3053\u306e\u6587\u7ae0\u304b\u3089\u3001\u4f5c\u7528\u6a5f\u5e8f\u3092\u8868\u793a\u3059\u308b\u5834\u5408\u306e\u8981\u4ef6
\u306b\u3064\u3044\u3066\u30013\u3064\u306b\u5206\u89e3\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n
\uff08\uff11\uff09\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u304f\u6a5f\u80fd\u6027\u3092\u6d88\u8cbb\u8005\u306b\u6b63
\u3057\u304f\u4f1d\u3048\u308b\u305f\u3081\u306b\u4f5c\u7528\u6a5f\u5e8f\u3092\u8868\u793a\u3059\u308b\u3053\u3068\u304c\u5fc5
\u8981\u306a\u5834\u5408
\uff08\uff12\uff09\u30d2\u30c8\u306b\u304a\u3051\u308b\u4f5c\u7528\u6a5f\u5e8f\u306b\u3064\u3044\u3066\u51fa\u5178\u3092\u660e
\u8a18\u306e\u4e0a\u3001in vitro \u8a66\u9a13\u53c8\u306fin vivo \u8a66\u9a13\u306b\u3088\u308a
\u4f5c\u7528\u6a5f\u5e8f\u3092\u8a55\u4fa1\u3057\u305f\u5834\u5408\u306e\u30d2\u30c8\u3078\u306e\u5916\u633f\u6027\u306b\u3064
\u3044\u3066\u8aac\u660e\u3059\u308b\u3053\u3068\u3082\u542b\u3081\u79d1\u5b66\u7684\u306b\u8aac\u660e\u3059\u308b\u3002
\uff08\uff13\uff09\u4f5c\u7528\u6a5f\u5e8f\u304c\u3042\u305f\u304b\u3082\u79d1\u5b66\u7684\u6839\u62e0\u306b\u57fa\u3065\u304f
\u6a5f\u80fd\u6027\u306e\u8868\u793a\u3067\u3042\u308b\u3068\u6d88\u8cbb\u8005\u306b\u8aa4\u8a8d\u3092\u4e0e\u3048\u306a\u3044\u3002<\/p>\n\n\n\n
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\u307e\u3059\u3002\u3053\u308c\u306f\u7686\u3055\u3093\u3082\u3088\u304f\u3054\u5b58\u3058\u3060\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n
\uff08\uff13\uff09\u306f\u8868\u73fe\u306e\u554f\u984c\u3067\u3059\u3002\u3069\u3046\u3044\u3046\u3053\u3068\u304b\u3068\u8a00
\u3046\u3068\u3001\u4f8b\u3048\u3070\u3001\u300c\u3007\u3007\u3092\u6e1b\u5c11\u3055\u305b\u308b\u4f5c\u7528\u306b\u3088\u308a
\u2025\u30fb\u300d\u3001\u3053\u3046\u3044\u3046\u4f5c\u7528\u6a5f\u5e8f\u306e\u8868\u73fe\u306f\u3001\u300c\u6e1b\u5c11\u300d
\u3068\u3044\u3046\u7d50\u679c\u3092\u8868\u3059\u8a9e\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u6a5f\u80fd\u6027\u3068
\u8aa4\u8a8d\u3055\u305b\u308b\u305f\u3081\u306bNG\u3067\u3059\u3002\u300c\u7de9\u548c\u300d\u300c\u7dad\u6301\u300d
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\u3089\u308c\u307e\u3059\u3002<\/p>\n\n\n\n
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\u5e81\u304b\u3089\u306e\u4f5c\u7528\u6a5f\u5e8f\u306b\u95a2\u3059\u308b\u5dee\u623b\u3057\u30b3\u30e1\u30f3\u30c8\u3092\u898b
\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n
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\u6d88\u8cbb\u8005\u306b\u6b63\u3057\u304f\u4f1d\u3048\u308b\u305f\u3081\u306b\u4f5c\u7528\u6a5f\u5e8f\u3092\u8868\u793a\u3059
\u308b\u3053\u3068\u304c\u5fc5\u8981\u306a\u5834\u5408\u3001\u8868\u793a\u3057\u3088\u3046\u3068\u3059\u308b\u6a5f\u80fd\u6027
\u306b\u4f5c\u7528\u6a5f\u5e8f\u3092\u542b\u3081\u3066\u8868\u793a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u300d
\u3092\u8e0f\u307e\u3048\u3001\u4f5c\u7528\u6a5f\u5e8f\u3092\u8868\u793a\u3059\u308b\u3053\u3068\u304c\u5fc5\u8981\u3067\u3042
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\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3001\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n
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\u683c\u306b\u9069\u7528\u3055\u308c\u3066\u3044\u308b\u304b\u306b\u3064\u3044\u3066\u306f\u3001\u30d1\u30c3\u3068\u898b\u305f
\u9650\u308a\u3067\u306f\u4e0d\u660e\u78ba\u306a\u3068\u3053\u308d\u304c\u3042\u308a\u307e\u3059\u3002\u4f8b\u3048\u3070\u5148
\u9031\u306e\u8a71\u984c\u3067\u3042\u308b\u6297\u9178\u5316\u4f5c\u7528\u3067\u3059\u304c\u3001\u300c\u6297\u9178\u5316\u4f5c
\u7528\u306b\u3088\u308a\u8a8d\u77e5\u6a5f\u80fd\u3092\u7dad\u6301\u3059\u308b\u300d\u3068\u8a00\u3063\u305f\u8da3\u65e8\u306e
\u8868\u73fe\u3092\u8003\u3048\u3066\u307f\u308b\u3068\u3001\u3053\u306e\u300c\u6297\u9178\u5316\u4f5c\u7528\u306b\u3088
\u308a\u300d\u306b\u5fc5\u8981\u6027\u304c\u3042\u308b\u306e\u304b\u306f\u3001\u7591\u554f\u304c\u6b8b\u308b\u3068\u3053\u308d
\u3067\u3059\u3002<\/p>\n\n\n\n
\u3068\u306a\u308b\u3068\u3001\u8981\u4ef6(\uff11\uff09\u306f\u305d\u308c\u307b\u3069\u6c17\u306b\u3057\u306a\u304f\u3066\u3082
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\u307b\u3069\u306e\u5dee\u623b\u3057\u30b3\u30e1\u30f3\u30c8\u3068\u77db\u76fe\u3057\u307e\u3059\u3002\u6d88\u8cbb\u8005\u5e81
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\u80fd\u6027\u3092\u6d88\u8cbb\u8005\u306b\u6b63\u3057\u304f\u4f1d\u3048\u308b\u305f\u3081\u300d\u306a\u306e\u3067\u3001\u5e83
\u544a\u3067\u306e\u8a34\u6c42\u306b\u4f7f\u3044\u305f\u3044\u3001\u306f\u3082\u3061\u308d\u3093\u30c0\u30e1\u3067\u3059\u3057\u3001
\u79d1\u5b66\u7684\u6839\u62e0\u306e\u88dc\u8db3\u3068\u3057\u3066\u3001\u3067\u3082\u5c11\u3057\u5f31\u3044\u611f\u3058\u304c
\u3057\u307e\u3059\u3002<\/p>\n\n\n\n
\u4f8b\u3048\u3070\u3053\u3093\u306a\u6761\u4ef6\u3092\u6e80\u305f\u3059\u8ad6\u7406\u69cb\u6210\u306a\u3089\u3001\u786c\u3044
\u3068\u8a00\u3048\u308b\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\u3002
(i)\u4f5c\u7528\u6a5f\u5e8f\u3092\u8868\u793a\u3057\u306a\u3044\u3068\u3001\u6a5f\u80fd\u6027\u306e\u610f\u5473\u306b
\u3064\u3044\u3066\u6d88\u8cbb\u8005\u306b\u8aa4\u8a8d\u304c\u751f\u3058\u308b
(ii)\u305d\u306e\u8aa4\u8a8d\u304c\u3001\u4f5c\u7528\u6a5f\u5e8f\u3092\u793a\u3059\u4ee5\u5916\u306b\u9632\u6b62\u624b
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