\u3053\u3093\u306b\u3061\u306f\u3002YDC\u306e\u30df\u30c3\u30b7\u30fc\u3067\u3059\u3002<\/p>\n\n\n\n
\u305d\u308c\u3067\u306f\u6a5f\u80fd\u6027\u8868\u793a\u6700\u65b0\u60c5\u5831\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n
J1509\u3000\uff23\uff32\uff2c\uff08\u30b7\u30fc\u30a2\u30fc\u30eb\u30a8\u30eb\uff09\uff11\uff15\uff10\uff15\u4e73
\u9178\u83cc\u30bf\u30d6\u30ec\u30c3\u30c8\uff34
\u300c\u672c\u54c1\u306b\u306fCRL1505\u4e73\u9178\u83cc\uff08L. rhamnosus
CRL1505\uff09\u304c\u542b\u307e\u308c\u307e\u3059\u3002CRL1505\u4e73\u9178\u83cc\u306f\u3001
pDC\uff08\u30d7\u30e9\u30ba\u30de\u30b5\u30a4\u30c8\u30a4\u30c9\u6a39\u72b6\u7d30\u80de\uff09\u306b\u50cd\u304d\u304b
\u3051\u3001\u5065\u5eb7\u306a\u4eba\u306e\u514d\u75ab\u6a5f\u80fd\u306e\u7dad\u6301\u306b\u5f79\u7acb\u3064\u3053\u3068\u304c
\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u300d<\/p>\n\n\n\n
\u5c4a\u51fa\u8005\u306f\u6771\u6d0b\u65b0\u85ac\u3055\u3093\u3002CRL1505\u4e73\u9178\u83cc\u306f\uff16\u4f8b
\u76ee\u3068\u306a\u308b\u514d\u75ab\u8a34\u6c42\u304c\u53ef\u80fd\u306a\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206\u3067\u3059\u3002
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\u9055\u3046\u70b9\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n
pDC\u3078\u8a00\u53ca\u3057\u3066\u3044\u306a\u3044\u30e6\u30fc\u30b0\u30ec\u30ca\u30b0\u30e9\u30b7\u30ea\u30b9\uff25
\uff2f\uff24\uff0d\uff11\u682a\u7531\u6765\u30d1\u30e9\u30df\u30ed\u30f3\u306e\u4e8b\u4f8b\uff08\u300c\u514d\u75ab\u7d30\u80de
\uff08\u5358\u7403\u3001\u30ca\u30a4\u30fc\u30d6\uff34\u7d30\u80de\uff09\u306e\u50cd\u304d\u300d\u3068\u3057\u3066\u3044
\u308b\uff09\u3092\u9664\u304d\u3001\u30d7\u30e9\u30ba\u30de\u4e73\u9178\u83cc\u3001L-92\u4e73\u9178\u83cc\u3001\u9162
\u9178\u83ccGK-1\u3001\u30e9\u30af\u30c8\u30d5\u30a7\u30ea\u30f3\u306e\u3044\u305a\u308c\u306e\u5834\u5408\u3067\u3082\u3001
\u4e3b\u306bpDC\u6d3b\u6027\u5316\u306e\u8a55\u4fa1\u6307\u6a19\u3068\u3057\u3066\u63a1\u7528\u3055\u308c\u3066\u3044
\u308b\u306e\u306fHLA-DR\u3001CD86\u306a\u3069\u3067\u3057\u305f\u3002<\/p>\n\n\n\n
J1509\u3067\u3082\u540c\u69d8\u306bHLA-DR\u3001CD86\u3092\u8a55\u4fa1\u3057\u3066\u3044\u307e
\u3059\u304c\u3001\u305d\u308c\u306b\u52a0\u3048\u3066PBMC\u306eIFN-\u03b1\u907a\u4f1d\u5b50
\u767a\u73fe\u91cf\u3068\u3044\u3046\u306e\u3082\u3001pDC\u6d3b\u6027\u5316\u306e\u6307\u6a19\u3068\u306a\u3063\u3066
\u3044\u307e\u3059\u3002\u3053\u306ePMBC\u306b\u3064\u3044\u3066\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u8aac\u660e
\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n
\u300cpDC \u306f\u514d\u75ab\u7d30\u80de\u306b\u304a\u3051\u308b\u4e3b\u8981\u306aI \u578bIFN\u7523\u751f
\u7d30\u80de\u3067\u3042\u308a\u3001PBMC\u306b\u304a\u3044\u3066\u6d3b\u6027\u5316\u3057\u305fpDC \u306f\u4ed6
\u306e\u514d\u75ab\u7d30\u80de\u3068\u6bd4\u8f03\u3057\u3066 200~1000 \u500d\u306eIFN-\u03b1
\u7523\u751f\u80fd\u3092\u793a\u3057\u300195%\u4ee5\u4e0a\u306eI \u578bIFN \u7523\u751f\u3092\u62c5\u3046\u3002
\u3057\u305f\u304c \u3063\u3066\u3001CRL1505 \u4e73\u9178\u83cc(L. rhamnosus
CRL1505)\u52a0\u71b1\u6b7b\u83cc\u4f538.8 \u5104\u500b\/\u65e5\u306e\u6442\u53d6\u306b\u3088 \u308b
PBMC \u306b\u304a\u3051\u308bIFN-\u03b1 \u907a\u4f1d\u5b50\u306e\u6709\u610f\u306a\u9ad8\u767a\u73fe\u306f\u3001
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PBMC\u306f8\u9031\u6642\u70b9\u3067\u5b9f\u6e2c\u5024\u306b\u6709\u610f\u5dee\u3042\u308a\u3068\u306a\u3063\u3066
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\u3048\u307e\u3059\u3002<\/p>\n\n\n\n
PBMC\u5358\u4f53\u3092pDC\u6d3b\u6027\u306e\u6307\u6a19\u3068\u3057\u3066\u6d88\u8cbb\u8005\u5e81\u304c\u8a8d
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\u306a\u304a\u3001\u6700\u5f8c\u306b\u3082\u3046\u4e00\u3064\u4eca\u56de\u306e\u4e8b\u4f8b\u306e\u6ce8\u76ee\u70b9\u3092\u6319
\u3052\u308b\u3068\u3001\u305d\u308c\u306f\u6a5f\u80fd\u6027\u95a2\u4e0e\u6210\u5206CRL1505\u4e73\u9178\u83cc
\u306e\u6442\u53d6\u91cf\u304c8.8\u5104\u500b\u3067\u3042\u308b\u3053\u3068\u3067\u3059\u3002\u7a2e\u304c\u9055\u3046
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\u83cc1000\u5104\u500b\u3001L-92\u4e73\u9178\u83cc200\u5104\u500b\u3068\u6bd4\u3079\u308b\u3068\u5727
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\u304d\u306a\u5dee\u304c\u51fa\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u306d\u3002<\/p>\n\n\n\n
\u305d\u308c\u3067\u306f\u3001\u307e\u305f\u30e1\u30fc\u30eb\u3057\u307e\u3059\u306d\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"
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