{"id":46317,"date":"2023-09-20T23:15:42","date_gmt":"2023-09-20T14:15:42","guid":{"rendered":"https:\/\/www.yakujihou.com\/kinousei\/?post_type=rare-case&p=46317"},"modified":"2023-09-20T23:16:05","modified_gmt":"2023-09-20T14:16:05","slug":"rare053","status":"publish","type":"rare-case","link":"https:\/\/www.yakujihou.com\/kinousei\/data\/rare-case\/rare053\/","title":{"rendered":"53\uff0e\u30aa\u30ea\u30fc\u30d6\u7531\u6765\u30d2\u30c9\u30ed\u30ad\u30b7\u30c1\u30ed\u30bd\u30fc\u30eb\u2192\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u4f4e\u4e0b\uff08\u3055\u304f\u3089\u30d5\u30a9\u30ec\u30b9\u30c8\u4e8b\u4ef6\uff083\uff09\uff09"},"content":{"rendered":"\t\t
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    HT\u306e\u4f53\u5185\u52d5\u614b\u306b\u95a2\u3059\u308b\u7a2e\u3005\u306e\u7814\u7a76\uff08*2\uff0c3\uff0c4\uff09\u304b\u3089\u3001HT\u4ee3\u8b1d\u7269\u306e\u8840\u4e2d\u53ca\u3073\u5c3f\u4e2d\u306e\u6d88\u5931\u304c\u6bd4\u8f03\u7684\u65e9\u3044\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u308b\uff08\u8840\u4e2d\uff1a12\u6642\u9593\u4ee5\u5185\u3001\u5c3f\u4e2d\uff1a24\u6642\u9593\u4ee5\u5185\uff09\u3002\u672c\u7814\u7a76\u30ec\u30d3\u30e5\u30fc\u306e\u63a1\u7528\u8ad6\u6587\u3067\u306f\u3044\u305a\u308c\u30822\u9031\u9593\u306e\u30a6\u30a9\u30c3\u30b7\u30e5\u30a2\u30a6\u30c8\u671f\u9593\u3092\u8a2d\u5b9a\u3057\u3066\u304a\u308a\u3001HT\u306e\u4f53\u5185\u52d5\u614b\u3092\u8003\u616e\u3059\u308b\u3068\u3001\u6301\u3061\u8d8a\u3057\u52b9\u679c\u306e\u5f71\u97ff\u306f\u8003\u3048\u306b\u304f\u3044\u3053\u3068\u304b\u3089\u3001\u30af\u30ed\u30b9\u30aa\u30fc\u30d0 \u30fc\u8a66\u9a13\u3092\u63a1\u7528\u3057\u3066\u554f\u984c\u306a\u3044\u3068\u8003\u3048\u308b\u3002<\/p>

    \u00a0<\/p>

    \u8ad6\u20103\u306b\u304a\u3051\u308b\u9178\u5316LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\uff08\u672c\u30de\u30fc\u30ab\u30fc\uff09\u306e\u7d71\u8a08\u89e3\u6790\u306b\u304a\u3044\u3066\u306f\u3001\u7d71\u8a08\u89e3\u6790\u30bd\u30d5\u30c8\u3067\u3042\u308bSPSS\u3092\u7528\u3044\u3001\u307e\u305a\u201cgeneral linearmodel with repeated measures test\u201d\u3001\u3059\u306a\u308f\u3061\u3001\u53cd\u5fa9\u6e2c\u5b9a\u306e2\u5143\u914d\u7f6e\u5206\u6563\u5206\u6790\u3092\u884c\u3063\u3066\u3044\u308b\u3002\u8ad6\u20103\u306e\u7b2c3.5\u9805\u201cEffect on postprandial redox status biomarkers after HT consumption\u201d\u306b\u304a\u3044\u3066\u201coxidised-LDL concentration significantly decreased after HT-B intake in comparison with C-B (p = 0.041)\u201d\u3068\u8a18\u8f09\u3055\u308c\u3066\u3044\u308b\u901a\u308a\u3001\u56e0\u5b50_biscuit type (HT-B\uff1a\u4ecb\u5165\u98df\u3001C-B\uff1a\u30d7\u30e9\u30bb\u30dc\u98df\uff09\u306b\u3064\u3044\u3066\u7fa4\u9593\u5dee\u304c\u8a8d\u3081\u3089\u308c\uff08p = 0.041\uff09\u3001\u56e0\u5b50_time\uff080,0.5,1,2,3,4,5,6\uff09\u306b\u3064\u3044\u3066\u3082\u3069\u3053\u304b\u306e\u6642\u70b9\u3067\u672c\u30de\u30fc\u30ab\u30fc\u306b\u5dee\u304c\u3042\u308b\u3053\u3068\u304c\u5f37\u304f\u793a\u5506\u3055\u308c\u305f\uff08p < 0.001\uff09\u3002\u307e\u305f2\u3064\u306e\u56e0\u5b50\u306b\u306f\u4ea4\u4e92\u4f5c\u7528\u304c\u306a\u3044\u3053\u3068\u304c\u5206\u304b\u3063\u305f\uff08which showed no interaction between factors time and biscuit type (Fig. 2D).\uff09\u3002<\/p>

    \u00a0<\/p>

    \u7d9a\u3044\u3066\u5404\u6642\u70b9\u3067\u7fa4\u9593\u5dee\u304c\u3042\u308b\u306e\u304b\u691c\u8a3c\u3059\u308b\u76ee\u7684\u3067\u3001\u3055\u3089\u306b\u7fa4\u9593\u6bd4\u8f03\u3092\u5b9f\u884c\u3057\u3066\u3044\u308b\u3002\u5404\u6642\u70b9\u3067\u306e\u7fa4\u9593\u6bd4\u8f03\u306b\u304a\u3044\u3066\u306f\u3001SPSS\u3092\u7528\u3044\u305f\u201cBonferroni test\u201d\u3001\u3059\u306a\u308f\u3061\u591a\u91cd\u6027\u3092\u8003\u616e\u3057\u305fT\u691c\u5b9a\u306b\u3066\u691c\u8a3c\u3057\u3066\u3044\u308b\u3002\u305d\u306e\u7d50\u679c\u3001\u6442\u53d630\u5206\u5f8c\u30684\u6642\u9593\u5f8c\u3067\u3001C-B\u7fa4\u3068\u6bd4\u3057\u3066HT-B\u7fa4\u306e\u672c\u30de\u30fc\u30ab\u30fc\u304c\u6709\u610f\u306b\u4f4e\u5024\u3092\u793a\u3057\u305f\u3002\u3053\u306e\u3053\u3068\u306f\u3001\u4e0a\u8ff0\u3057\u305f2\u5143\u914d\u7f6e\u5206\u6563\u5206\u6790\u306e\u7fa4\u9593\u3067\u306e\u6709\u610f\u5dee\u306e\u7d50\u679c\u3092\u5f37\u304f\u652f\u6301\u3059\u308b\u3002\u307e\u305f\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3067\u306f\u3001\u672c\u30de\u30fc\u30ab\u30fc\u306b\u3064\u3044\u3066\u4e21\u7fa4\u306e\u9593\u306b\u6709\u610f\u5dee\u306f\u691c\u51fa\u3055\u308c\u306a\u304b\u3063\u305f\u3053\u3068\u304b\u3089\u3001C-B\u7fa4\u3068HT-B\u7fa4\u3068\u306e\u672c\u30de\u30fc\u30ab\u30fc\u306e\u7fa4\u9593\u5dee\u306f\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u306e\u5dee\u306b\u8d77\u56e0\u3057\u305f\u5dee\u3067\u306f\u306a\u3044\u3053\u3068\u304c\u63a8\u5bdf\u3055\u308c\u305f\u3002\u3059\u306a\u308f\u3061\u3001C-B\u7fa4\u3068\u6bd4\u3057\u3066HT-B\u7fa4\u306b\u304a\u3051\u308b\u672c\u30de\u30fc\u30ab\u30fc\u306f\u3001\u4ecb\u5165\u5f8c\u306e\u5168\u6e2c\u5b9a\u6642\u70b9\u3092\u901a\u3057\u3066\u4f4e\u5024\u63a8\u79fb\u3059\u308b\u3053\u3068\u304c\u63a8\u5bdf\u3055\u308c\u308b\u3068\u3068\u3082\u306b\u3001\u5b9f\u969b\u306b\u6442\u53d630\u5206\u5f8c\u30684\u6642\u9593\u5f8c\u3067\u7fa4\u9593\u5dee\u304c\u8a8d\u3081\u3089\u308c\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002<\/p>

    \u00a0<\/p>

    \u306a\u304a\u3001\u6b27\u5dde\u98df\u54c1\u5b89\u5168\u6a5f\u95a2\uff08EFSA\uff09\u306b\u3088\u308b\u30aa\u30ea\u30fc\u30d6\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306e\u5065\u5eb7\u5f37\u8abf\u8868\u793a\u306e\u8a55\u4fa1\uff08*5\uff09\u306b\u304a\u3051\u308b\u201c5. Conditions and possible\u3000restrictions of use – 5.1. Protection of LDL particles from oxidative damage\u201d\u306e\u9805\u3067\u306f\u3001HT\u304a\u3088\u3073\u305d\u306e\u985e\u7e01\u4f53(\u30aa\u30ec\u30a6\u30ed\u30da\u30a4\u30f3\u3001\u30c1\u30ed\u30bd\u30fc\u30eb\u7b49)\u30925 mg\/\u65e5\u3067\u542b\u3080\u98df\u54c1\u306b\u304a\u3044\u3066\u3001\u8840\u4e2dLDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u9178\u5316\u6291\u5236\u4f5c\u7528\u306b\u95a2\u3059\u308b\u5065\u5eb7\u5f37\u8abf\u8868\u793a\u3092\u8a8d\u3081\u3066\u3044\u308b\u3002\u4e00\u65e5\u3042\u305f\u308a\u306e\u6442\u53d6\u76ee\u5b89\u91cf5.25mg\u3068\u540c\u91cf\u306e\u8a66\u9a13\u7d50\u679c\u3067\u3042\u308b\u8ad6-3\u306e\u7d50\u679c\u306f\u3001EFSA\u306e\u8a55\u4fa1\u306b\u304a\u3051\u308b\u6442\u53d6\u91cf\u304a\u3088\u3073\u9178\u5316\u6291\u5236\u6a5f\u80fd\u304b\u3089\u5927\u304d\u304f\u7570\u306a\u308b\u3082\u306e\u3067\u306f\u306a\u304f\u3001\u4e00\u8cab\u6027\u306e\u3042\u308b\u3082\u306e\u3068\u8003\u3048\u308b\u3002<\/p>

    \u00a0<\/p>

    \u203b\u88dc\u8db3\u8aac\u660e\uff1a\u89e3\u6790\u306e\u6982\u8981
    \u5f53\u8ad6\u6587\u3067\u306f\u3001\u4e3b\u306b2\u3064\u306e\u7d71\u8a08\u89e3\u6790\u624b\u6cd5\u306b\u3088\u308a\u3001HT\u6295\u4e0e\u306b\u3088\u308b\u9178\u5316LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5024\uff08LDL\uff09\u6e1b\u5c11\u52b9\u679c\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u2460\u5168\u6642\u70b9\u30c7\u30fc\u30bf\u3092\u7dcf\u5408\u3057\u3066\u89e3\u91c8\u3057\u305f\u7d50\u679c\u3001C-B\u7fa4\u3068\u6bd4\u8f03\u3057\u3066\u3001HT-B\u7fa4\u3067\u306f\u3001LDL\u304c\u6709\u610f\u306b\u4f4e\u5024\u3092\u793a\u3057\u3001\u2461\u5404\u6642\u70b9\u306e\u7fa4\u9593\u5dee\u3092\u8a73\u7d30\u306b\u6bd4\u8f03\u3057\u305f\u7d50\u679c\u3001\u5b9f\u969b\u306b\u6442\u53d630\u5206\u5f8c\u3068\uff14\u6642\u9593\u5f8c\u3067\u3001C-B\u7fa4\u3068\u6bd4\u8f03\u3057\u3066HT-B\u7fa4\u306b\u304a\u3051\u308bLDL\u304c\u6709\u610f\u306b\u4f4e\u5024\u3092\u793a\u3057\u305f\u304c\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3067\u306f\u6709\u610f\u5dee\u304c\u691c\u51fa\u3055\u308c\u306a\u304b\u3063\u305f\u3002\u3059\u306a\u308f\u3061\u2460\u3001\u2461\u306e\u7d50\u679c\u304b\u3089\u3001C-B\u7fa4\u3068\u6bd4\u3057\u3066HT-B\u7fa4\u306b\u304a\u3051\u308bLDL\u306f\u3001\u4ecb\u5165\u5f8c\u306e\u5168\u6e2c\u5b9a\u6642\u70b9\u3092\u901a\u3057\u3066\u4f4e\u5024\u63a8\u79fb\u3059\u308b\u3053\u3068\u304c\u63a8\u5bdf\u3055\u308c\u308b\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

    \n\t\t\t\t
    \n\t\t\t\t\t\t\t
    \n\t\t\t
    \n\t\t\t<\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
    \n\t\t\t\t
    \n\t\t\t\t\t\t\t\t\t

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